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Dictionary termTrack CStablev2026.2

Reproducibility crisis

The widely reported finding that substantial proportions of published research, particularly in biomedical, psychological, and social sciences, fail to reproduce or replicate when re-tested.

ByCASRAI Editorial Board
· Last updated 21 May 2026

Examples

Worked examples

  • Is an instance

    The 2015 OSC psychology replication rate of ~39%.

  • Is an instance

    The Reproducibility Project: Cancer Biology's findings on the difficulty of reproducing landmark preclinical results.

Counter-examples

Looks similar, but isn't

  • Not an instance

    A single failed replication of an individual study.

  • Not an instance

    Normal scientific revision through new evidence.

Editorial commentary

The 'crisis' framing follows Ioannidis (2005) 'Why most published research findings are false', the Open Science Collaboration's 2015 psychology project (~39% of 100 effects successfully replicated), and subsequent large-scale efforts. Subsequent literature debates whether 'crisis' or 'credibility revolution' is the more accurate term; either framing motivates the methodological reforms catalogued under open science.

References

  • Ioannidis, 'Why most published research findings are false' (PLOS Medicine, 2005); Open Science Collaboration (Science, 2015); Baker, '1,500 scientists lift the lid on reproducibility' (Nature, 2016).

Also known as

replication crisis · credibility crisis

Machine-readable encodings

Use in your systems

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Schema.org DefinedTerm (JSON-LD)
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Referenced across the research world

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