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v2026.1714 entries · CC-BY 4.0
Dictionary termTrack CStablev2026.2

NIH Rigor and Reproducibility policy

The set of US National Institutes of Health policies, effective from 2016, requiring applicants and grantees to address scientific premise, scientific rigour, biological variables (including sex as a biological variable), and authentication of key biological and chemical resources in grant applications.

ByCASRAI Editorial Board
· Last updated 21 May 2026

Examples

Worked examples

  • Is an instance

    An NIH R01 application addressing sex as a biological variable and providing an authentication plan for the cell lines used.

  • Is an instance

    A progress report attesting to mid-grant compliance with the authentication plan.

Counter-examples

Looks similar, but isn't

  • Not an instance

    An NSF Data Management Plan (different policy).

  • Not an instance

    A journal reporting standard.

Editorial commentary

The policy emerged in response to the preclinical reproducibility literature (Begley & Ellis, 2012; Freedman et al., 2015). Implementation appears in the NIH SF424 application instructions across most institutes. Compliance is now built into application review criteria and progress reports.

References

  • NIH Notice NOT-OD-15-103 'Enhancing Reproducibility through Rigor and Transparency'; NIH SF424 application guide.

Also known as

NIH R&R policy · NIH Rigor policy

Machine-readable encodings

Use in your systems

JATS XML <role> element
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Schema.org DefinedTerm (JSON-LD)
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Adopted by research universities worldwide

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