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Direct comparison

Know-How License vs. Patent License

How know-how and patent licenses differ in scope, term, and royalties -- and why biotech deals typically bundle both.

Side-by-side comparison

DimensionKnow-How LicensePatent License
What is licensedConfidential technical information: processes, formulations, protocols, operational know-howRights under a specific granted patent (or pending application) claim set
Legal basisTrade-secret law (DTSA, state UTSA statutes) plus contractual confidentiality obligationsPatent Act, 35 U.S.C., as administered by the USPTO
Disclosure required to obtain the rightNone -- protection depends on keeping the information secretFull public disclosure of the claimed invention, in exchange for the exclusionary right
How the licensee learns to use itActive technology transfer -- documentation, training, technical support from the licensorReading the published patent; no transfer obligation on the licensor beyond the grant itself
TermNo fixed statutory ceiling -- runs as long as the agreement specifies or the information stays secretCapped at the patent term -- 20 years from the earliest non-provisional filing date
Effect of the underlying right lapsingIf the information becomes public (independent discovery, lawful reverse engineering), the exclusivity basis disappearsOnce the patent expires, the invention is dedicated to the public and anyone may practice it royalty-free
Royalties after the underlying right endsCan lawfully continue if the licensee still uses the confidential information and the agreement structures it as a genuine know-how royaltyCannot lawfully continue past patent expiration on their own -- Brulotte v. Thys Co. (1964), reaffirmed in Kimble v. Marvel (2015)
Remedy if a third party gets the same information/invention independentlyNo remedy against independent discovery or lawful reverse engineering -- only misappropriation is actionablePatent infringement does not require copying -- independent invention is not a defense
Enforcement mechanismBreach-of-contract and trade-secret-misappropriation claimsPatent infringement claims under 35 U.S.C.

Common questions

FAQ

Can a know-how license exist without any patent at all?+

Yes. Manufacturing-process, software, and early-stage biological-material licenses are often pure know-how licenses with no patent component, enforced through contractual confidentiality and trade-secret law rather than patent infringement.

Why do biotech licenses so often combine patent and know-how rights?+

Because a patent's claims often do not capture the tacit manufacturing and process knowledge needed to reliably reproduce the invention, and because a properly structured hybrid license can lawfully continue know-how royalties after the patent expires, extending the commercial life of the deal.

Can royalties continue after a licensed patent expires?+

Not as a pure patent royalty -- Brulotte v. Thys Co. and Kimble v. Marvel Entertainment make that unenforceable. A hybrid license with a genuine, appropriately reduced know-how royalty component can continue past expiration.

Referenced across the research world

University of Cambridge logoColumbia University logoCrossref logoUniversity of Edinburgh logoHarvard University logoUniversity of Oxford logoPrinceton University logoStanford School of Medicine logoUniversity College London logoORCID logoUniversity of Cambridge logoColumbia University logoCrossref logoUniversity of Edinburgh logoHarvard University logoUniversity of Oxford logoPrinceton University logoStanford School of Medicine logoUniversity College London logoORCID logo
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