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Nextflow (concept)

A workflow orchestration system based on dataflow programming with a Groovy-based domain-specific language, designed for scalable, container-native, multi-platform execution of computational pipelines.

ByCASRAI Editorial Board
· Last updated 21 May 2026

Examples

Worked examples

  • Is an instance

    An nf-core/rnaseq pipeline run on AWS Batch using Singularity images.

  • Is an instance

    A custom Nextflow workflow distributed alongside a paper with a pinned configuration profile.

Counter-examples

Looks similar, but isn't

  • Not an instance

    A Snakemake pipeline (different ecosystem).

  • Not an instance

    A non-workflow shell script.

Editorial commentary

Nextflow's processes communicate via typed channels, enabling implicit parallelism and easy scaling from laptop to HPC to cloud. The nf-core community curates dozens of standardised, peer-reviewed pipelines. As with Snakemake, this entry covers the conceptual pattern rather than version-specific behaviour.

References

  • Di Tommaso et al., 'Nextflow enables reproducible computational workflows' (Nature Biotechnology, 2017); nf-core community publications.

Also known as

Nextflow

Machine-readable encodings

Use in your systems

JATS XML <role> element
xml
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      vocab-term="Nextflow (concept)"
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Schema.org DefinedTerm (JSON-LD)
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Referenced across the research world

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