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Mosquito repellent and prevention in Puerto Rico: dengue, Zika and chikungunya

To prevent dengue, Zika and chikungunya in Puerto Rico, avoid bites from Aedes mosquitoes: use an EPA-registered repellent (with DEET, picaridin, IR3535, oil of lemon eucalyptus or PMD, or another EPA-registered ingredient), wear clothing that covers your skin, keep window and door screens in repair, and empty standing water from buckets, tires and plant saucers every week. If you already have a fever or rash, the doctor can see you by video.

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If the clinic can't see you, for example because of a technical problem on our side, we refund you in full.

Is this an emergency?

This is not an emergency service. Call 911 or go to the nearest emergency room if you have:

  • Fever with belly pain, repeated vomiting, or bleeding from the nose or gums (possible dengue warning signs)
  • Extreme tiredness, restlessness or irritability after several days of fever
  • Swelling of the face or tongue, trouble breathing, or hives all over the body after a bite or after using a product
  • Confusion, seizures, or a very bad headache with a stiff neck
  • A baby under 3 months with a temperature of 100.4 °F (38 °C) or higher

Warning signs: when to go to the ER

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Why bite prevention matters in Puerto Rico

According to the CDC, dengue, Zika and chikungunya spread through the bites of infected Aedes mosquitoes (Aedes aegypti and Aedes albopictus). No medicine cures these infections; treatment is supportive, so the best protection is avoiding the bite. We have guides to the symptoms and warning signs of dengue, Zika and chikungunya.

Aedes mosquitoes live close to people, inside and around the home, and lay their eggs in clean water that sits still in small containers. According to the CDC, they bite during the day, with activity often highest in the early morning and late afternoon, but they can also bite at night, especially in lit areas. That is why a bed net helps but is not enough on its own.

How to choose a repellent that works

Choose an EPA-registered repellent. That means the agency evaluated the product for safety and effectiveness when used as the label directs. According to the CDC and the EPA, the active ingredients recommended for repelling mosquitoes are:

  • DEET
  • Picaridin (also called icaridin)
  • IR3535
  • Oil of lemon eucalyptus (OLE) or para-menthane-diol (PMD)
  • 2-undecanone

How to read the label, and what to skip

The EPA has an online tool to search for repellents by how long you need protection and by active ingredient (search for the "EPA repellent search tool"). If you are unsure which product suits you, you can ask the doctor by video. Read the label: it tells you how long the product protects and how to apply it. A higher percentage of active ingredient protects for longer; it does not repel more strongly.

“Natural” repellents that are not EPA-registered have not been evaluated the same way, so we cannot rely on them to protect you from these diseases. We also know of no solid evidence that wristbands, ultrasonic devices or scented candles protect. We do not recommend brands in this guide.

How to apply repellent safely

According to the CDC and the EPA, always follow the directions on the product label. In general:

  • Apply it only on exposed skin and on top of clothing. Do not put it under clothing.
  • If you use sunscreen, put the sunscreen on first and the repellent after. Avoid combination sunscreen-repellent products: sunscreen needs to be reapplied more often than repellent.
  • Do not apply it over cuts, wounds or irritated skin. On the face, spray it into your hands first and apply carefully, keeping it away from your eyes and mouth.
  • Do not use spray repellent in a closed room or near food. Wash your hands afterward, and wash treated skin with soap and water when you come back indoors.
  • On children: apply it yourself, do not let them apply it, and do not put it on their hands, since they put them in their mouths and eyes.
  • Do not use repellent on babies under 2 months. Cover the stroller or crib with mosquito netting. Oil of lemon eucalyptus and PMD should not be used on children under 3 years, according to the CDC.

Repellent during pregnancy or breastfeeding

According to the CDC, EPA-registered repellents are safe for pregnant and breastfeeding women when used as the label directs. Because Zika and dengue during pregnancy can be serious, the CDC advises not skipping them. If you are pregnant, any decision about testing or follow-up belongs to your obstetric provider; we do not provide pregnancy care.

Clothing, home and bed nets

Repellent is only one part of protection. According to the CDC:

  • Wear long, loose-fitting shirts and pants. Mosquitoes can bite through tight clothing.
  • You can buy permethrin-treated clothing and gear, or treat your own clothes following the product label. Permethrin is for clothing and gear only, not for skin.
  • Use screens on doors and windows and repair any holes. Sleeping in an air-conditioned room with the windows closed reduces bites.
  • If you sleep somewhere without screens or air conditioning, use a bed net.

Get rid of standing water: rainy season and after a hurricane

Aedes mosquitoes lay their eggs in water that sits still, and the eggs can survive dry for months until it rains again. The rainy season and the weeks after a hurricane or storm are higher-risk times, because rain fills containers in the yard and on the roof. According to the CDC, once a week empty, scrub, turn over, cover or throw out containers that hold water.

Check these places: buckets and pails, old tires, saucers under plant pots, pet water bowls, vases, cans and bottles, clogged roof gutters, toys in the yard, tarps or awnings that collect water, and the base of bromeliads or other plants that hold water. Water tanks and cisterns should have tight-fitting lids and screening over any openings.

After a hurricane, water outages lead many families to store water in containers; keep them covered. For other health risks after a hurricane, such as contaminated water, heat and injuries, read health after a hurricane. If you were in floodwater and have a fever, see our leptospirosis guide.

If you see breeding sites in a public place or on an abandoned lot, you can report them to your municipality or the Department of Health.

If you were bitten: the bite and the itch

Most mosquito bites only cause an itchy bump that goes away in a few days. Wash the area with soap and water, use cold compresses, and avoid scratching so you do not break the skin. An over-the-counter hydrocortisone cream or an oral antihistamine can ease the itch, as the label directs. For more detail, see bug bites.

If the area becomes warm, red, swollen or has pus, or the redness spreads, it may be infected and is worth having the doctor look at by video.

If you already have a fever or rash

A bite does not cause a fever by itself. If, in the days or weeks after bites, you have a fever, headache, pain behind the eyes, muscle or joint pain, a rash or red eyes, it could be dengue, chikungunya, Zika or another infection. Only a lab test can tell them apart.

Dr. Diana Nieves Castro, a Puerto Rico–licensed general practice physician with several years of emergency-department experience, can see you by video. We evaluate, diagnose and treat; if needed, we give you a blood test order for a lab near you. See also our fever guide.

Until dengue is ruled out, the CDC says to avoid aspirin and other anti-inflammatory medicines (such as ibuprofen) because of the risk of bleeding; acetaminophen, rest and fluids are used for fever and pain. If appropriate, the doctor prescribes and we send your prescription to your pharmacy.

We see adults and children of all ages; for patients under 21, a parent or legal guardian stays on camera for the whole visit with photo ID. You need to be physically in Puerto Rico during the visit. Visiting? See our care for visitors.

Price and how to book

A doctor visit has the same price for every age, with no membership. Video doctor visits 24/7 — book online and choose your time right away. Your card is charged when you request it, and you get a full refund if the clinic can’t see you. We send you a secure video link that works on your phone, tablet or computer. The service is run by The Health Initiative, a nonprofit. Book your visit.

When to go to the ER

For your safety, with any of these signs call 911 or go to an emergency room, and don’t book a video visit. See when to go to the ER.

  • Fever with belly pain, repeated vomiting, or bleeding from the nose or gums (possible dengue warning signs)
  • Extreme tiredness, restlessness or irritability after several days of fever
  • Swelling of the face or tongue, trouble breathing, or hives all over the body after a bite or after using a product
  • Confusion, seizures, or a very bad headache with a stiff neck
  • A baby under 3 months with a temperature of 100.4 °F (38 °C) or higher

How we care for you

  • We evaluate, diagnose and treat; if needed, we give you a lab order for a lab near you.

  • We see adults and children of all ages. Patients under 21: a parent with patria potestad (parental authority) or a legal guardian is on camera for the whole visit and shows photo ID.

  • Real-time video visit. We send you a secure video link. It works on your phone, tablet or computer.

  • If appropriate, the doctor prescribes and we send your prescription to your pharmacy.

  • You must be physically in Puerto Rico during the visit (visitors, tourists and cruise passengers are welcome).

  • In an emergency, call 911.

Frequently asked questions

What is the best mosquito repellent for Puerto Rico?

One that is EPA-registered with an active ingredient the CDC recommends: DEET, picaridin, IR3535, oil of lemon eucalyptus, PMD or 2-undecanone. Read the label to see how long it protects.

How do I prevent dengue?

By avoiding Aedes mosquito bites: EPA-registered repellent, clothing that covers your skin, screens on doors and windows, and emptying standing water every week from buckets, tires, plant saucers and other containers. The CDC says preventing bites is the best protection.

Can pregnant people and children use repellent?

According to the CDC, EPA-registered repellents can be used during pregnancy and breastfeeding if you follow the label. On children, apply it yourself and not on their hands. Do not use it on babies under 2 months (cover the stroller with mosquito netting), and oil of lemon eucalyptus and PMD are not for children under 3.

Sunscreen or repellent first?

Sunscreen first, then repellent, according to the CDC. Avoid products that combine both, because sunscreen needs to be reapplied more often than repellent.

When do dengue mosquitoes bite the most?

Aedes mosquitoes bite during the day. According to the CDC, activity is often highest in the early morning and late afternoon, but they can bite at other times of day and sometimes at night.

What do I do about standing water after rain or a hurricane?

Once a week, empty, scrub, turn over, cover or throw out containers that hold water: buckets, tires, plant saucers, pet bowls and clogged gutters. Mosquitoes lay eggs in still water. Tanks and cisterns need lids and screening.

I have a fever after mosquito bites. What should I do?

If you have no warning signs, you can request a video visit with Dr. Nieves Castro, who evaluates you and, if needed, gives you a lab order. With belly pain, repeated vomiting or bleeding, go to the ER.

Video visit

$79· Doctor visit

Video doctor visits 24/7 — book online and choose your time right away.

Pay now, then choose your time right away. Full refund if you cancel 24 hours or more ahead.

See the cancellation policy

You can cancel for a full refund or change the time up to 24 hours before your visit. Within 24 hours you can't cancel and there's no refund. If you don't join in the first 10 minutes, there's no refund.

If you choose a time less than 24 hours away, it can't be cancelled or changed.

If the clinic can't see you, for example because of a technical problem on our side, we refund you in full.

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Medical care provided by Dr. Diana Nieves Castro, MD (PR license 24027)

About this page

Author: The Health Initiative

Medical care provided by Dr. Diana Nieves Castro, MD (PR license 24027)

Disclosure: Founding Executive Director of The Health Initiative

Published: 2026-10-10 · Updated: 2026-10-11