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24 hour pharmacy Puerto Rico: five verified all-night pharmacy counters

Name: 24 hour pharmacy Puerto Rico: 5 verified all-night | The Health Initiative
Published: 2026-09-30

Every 24 hour pharmacy Puerto Rico has that we could verify is a Walgreens: five pharmacy counters stay open all night, in Guaynabo, Bayamón, Caguas, Cayey and Ponce. Each closes 1:30–2 a.m. for a meal break. Many stores are open 24 hours while their pharmacy counter is not: an open store is not an open pharmacy. Verified October 2, 2026.

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This is not an emergency service. Call 911 or go to the nearest emergency room if you have:

Someone took too much of a medicine or the wrong one: call Poison Help, 1-800-222-1222
Swelling of the face or throat, or trouble breathing after a medicine: call 911
Chest pain, shortness of breath or signs of a stroke: call 911

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24 hour pharmacy Puerto Rico: the five counters open all night

The Walgreens 24-hour pharmacy locator returns only these five, whether you search from San Juan, Carolina, Fajardo, Humacao, Ponce or Mayagüez. All five have the store and the pharmacy counter open 24 hours, with a 1:30–2 a.m. meal break:

Walgreens, 2505 Carr 841, Guaynabo, PR 00969, 787-287-0528. The closest from San Juan, Condado and Isla Verde.
Walgreens, 4699 RR 5 (Route 5), Bayamón, PR 00956, 787-799-4699.
Walgreens, 101 Carr 1, Caguas, PR 00725, 787-744-2905. The closest from Fajardo and Humacao.
Walgreens, 5800 Ave Jesús T. Piñero, Cayey, PR 00736, 787-263-5166.
Walgreens, 2979 Ave Emilio Fagot, Ponce, PR 00716, 787-841-7400. The only one in the south, and the closest from Mayagüez and Aguadilla.

Verified October 2, 2026 on the Walgreens locator. We re-check this every three months, but hours change: call before you go, especially in the small hours. Need a new prescription at that hour? See a doctor online 24/7 by video; if appropriate, the doctor sends your prescription to one of these five counters.

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The doctor evaluates you and tells you what you most likely have and what to do.
If appropriate, she prescribes and we send your prescription to your pharmacy.
If needed, she gives you a lab order or a doctor’s note.

Before you request a visit, check the warning signs on this page. If you have any of them, do not wait: call 911 or go to the emergency room. See the warning signs

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A 24-hour store is not a 24-hour pharmacy

In the tourist areas, "24-hour Walgreens" almost always means the store, not the pharmacy counter where prescriptions are filled. Examples from each store's page, verified October 2, 2026:

Walgreens, 1130 Ashford Ave, Condado, 787-721-7895. Store: 24 hours. Pharmacy counter: Mon–Fri 8 a.m.–7 p.m., Sat 9 a.m.–6 p.m., Sun 9 a.m.–5 p.m.
Walgreens, 5984 Ave Isla Verde, Carolina, 787-982-0390. Store: 6 a.m.–midnight. Pharmacy counter: Mon–Fri 9 a.m.–7 p.m., Sat 9 a.m.–6 p.m., Sun 10 a.m.–6 p.m.
Walgreens, 200 Ave Fragoso, Carolina, 787-769-4122. Store: 24 hours. Pharmacy counter: daily 7 a.m.–11 p.m.
Walgreens, 2097 and 992 Ave Hostos, Mayagüez, 787-805-4805 and 787-831-9251. Store: 24 hours. Pharmacy counter: until 10 p.m.
Walgreens, 16000 Carr 2, Aguadilla, 787-882-8044. Store: 24 hours. Pharmacy counter: Mon–Fri 8 a.m.–7 p.m., Sat 9 a.m.–6 p.m., Sun 9 a.m.–2 p.m.

Counters that are not 24-hour also close 1:30–2 p.m. for a meal break. Farmacias Caridad has no 24-hour pharmacy counter: some stores, such as Isla Verde (8030 Calle Tartak) and Condado (1307 Ashford Ave), keep the shop floor open 24 hours, but the pharmacy closes in the afternoon or evening, per its store directory as checked on September 30, 2026.

What an open store can still sell you with the counter closed is over-the-counter medicine. For example, the FDA approved the levonorgestrel 1.5 mg morning-after pill for sale without a prescription and with no age limit; if the store keeps it locked up, ask at the register. Read our guide to the Plan B pill.

Which one is closest to you?

Where we give a distance, it is the Walgreens locator's straight-line figure, not a drive time:

San Juan and Río Piedras: Guaynabo.
Carolina, Isla Verde and the airport: Guaynabo or Caguas. See the Isla Verde guide.
Bayamón and Cataño: the Route 5 store in Bayamón. See the Bayamón and Cataño guide.
Caguas: the Carr 1 store. See the Caguas guide.
Fajardo and Ceiba: Caguas (25.7 miles) or Guaynabo (28.8 miles). Heading to Culebra or Vieques? Pick up medicines before the ferry. See the Fajardo and Ceiba guide.
Humacao: Caguas (15.7 miles) or Cayey (20.9 miles). See the Humacao guide.
Ponce and the south: the Emilio Fagot store, 1.9 miles. See the Ponce guide.
Mayagüez and Aguadilla: there is no 24-hour counter on the west coast; the nearest is Ponce (36.3 miles from Mayagüez). See the Mayagüez guide.

If you are far away at night, check whether you can wait for a counter near you to open in the morning.

Pharmacy open late: how we help if you need a prescription

At night: a doctor online in Puerto Rico, 24/7 by video; if appropriate, the doctor sends your prescription to a pharmacy open 24 hours.

Dr. Diana Nieves Castro, a Puerto Rico-licensed general practice physician with several years of emergency-department experience, sees you by video in English or Spanish. If appropriate, the doctor prescribes and we send your online prescription to your pharmacy: a Walgreens, a Farmacias Caridad or your community pharmacy. Pick a pharmacy counter that will still be open after your visit, especially at night. Every day, any time (Puerto Rico time).

If you need a medicine tonight, allow for the time until your visit and the counter's hours. If it is sold over the counter, an open store can tide you over.

A new problem is a doctor visit. If you forgot or lost a non-controlled medicine you already take, a refill is a follow-up visit: see lost prescription in Puerto Rico. You need to be physically in Puerto Rico during the visit, and visitors are welcome: see our care for tourists and visitors. Book a visit.

When it is not a pharmacy problem

If someone took too much of a medicine or the wrong one, call Poison Help at 1-800-222-1222, which serves Puerto Rico. For trouble breathing, swelling of the face or throat, chest pain or signs of a stroke, call 911. See when to go to the ER.

How we care for you

We evaluate, diagnose and treat; if needed, we give you a lab order for a lab near you.
We see adults and children of all ages. Patients under 21: a parent with patria potestad (parental authority) or a legal guardian is on camera for the whole visit and shows photo ID.
Real-time video visit. We send you a secure video link. It works on your phone, tablet or computer.
If appropriate, the doctor prescribes and we send your prescription to your pharmacy.
You must be physically in Puerto Rico during the visit (visitors, tourists and cruise passengers are welcome).
In an emergency, call 911.

Frequently asked questions

How many 24-hour pharmacies are there in Puerto Rico?

We verified five pharmacy counters that stay open all night, all Walgreens: Guaynabo (2505 Carr 841), Bayamón (4699 RR 5), Caguas (101 Carr 1), Cayey (5800 Ave Jesús T. Piñero) and Ponce (2979 Ave Emilio Fagot). They close 1:30–2 a.m. Verified October 2, 2026.

Is there a 24-hour pharmacy in San Juan?

San Juan has stores open 24 hours, but their pharmacy counters close at night. The nearest 24-hour counter is Walgreens, 2505 Carr 841, in Guaynabo.

Is there a 24-hour pharmacy in Isla Verde or Condado?

Not a 24-hour pharmacy counter. The Condado Walgreens store is open all night, but its counter closes at 7 p.m. on weekdays. The nearest 24-hour counters are in Guaynabo and Caguas.

Is there a 24-hour pharmacy on the west coast?

No. Mayagüez and Aguadilla have Walgreens stores open 24 hours, but their counters close at night. The nearest 24-hour counter is in Ponce.

How do I find a pharmacy open late in Puerto Rico?

Look for a 24-hour pharmacy counter, not just an open store: the five we verified are Walgreens in Guaynabo, Bayamón, Caguas, Cayey and Ponce. Call before you go. If you need a new prescription, request a video visit and pick one of those counters.

Is there a pharmacy open on Sunday?

Yes: the five Walgreens pharmacy counters we verified are open 24 hours, Sundays included, with a 1:30–2:00 a.m. break. Outside those five, many store pharmacies have shorter Sunday hours; the Condado counter, for example, is open 9:00 a.m. to 5:00 p.m. Call before you go.

Is there a 24 hour Walgreens in Carolina?

The Ave. Fragoso store in Carolina is open 24 hours, but its pharmacy counter runs 7:00 a.m. to 11:00 p.m. The closest 24-hour pharmacy counters from Carolina are in Guaynabo and Caguas. If you need a new prescription, book a video visit.

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